The utility model discloses a mold clamping mechanism for a novel hollow blow molding machine, comprising: a mold opening and closing base, a guide rail, a front platen, a rear platen, a mold shifting cylinder, a main mold, a mold base, tie rods, rear pull arms, a synchronization mechanism and a mold opening and closing cylinder. The guide rail is arranged at the upper end of the mold opening and closing base; the front platen is arranged on the left side of the upper end of the guide rail; the rear platen is arranged on the right side of the middle part of the guide rail; the mold shifting cylinder is arranged on the right side of the upper end of the guide rail; the mold base is arranged at the upper end of the mold shifting cylinder; the main mold is arranged at the upper end of the mold base; the synchronization mechanism is arranged on the guide rail between the mold base and the rear platen; the tie rods are arranged at the upper ends of the front platen and the main mold, and are connected with the front platen and the main mold through rear pull arms; the mold opening and closing cylinder is arranged on the right side of the rear platen. The device has simple structure, reasonable design and convenient operation. By adopting the way that the tie rods are not connected to the rear platen, the resistance is reduced, the movement is stable, the installation is convenient and fast, the efficiency is high, and it is convenient for large-scale popularization and application of this technology.